Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice.

@article{Wiersma2009HepaticSN,
  title={Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice.},
  author={Harmen Wiersma and Alberto Gatti and Niels Nijstad and Folkert Kuipers and Uwe J. F. Tietge},
  journal={Journal of lipid research},
  year={2009},
  volume={50 8},
  pages={1571-80}
}
High density lipoprotein cholesterol is thought to represent a preferred source of sterols secreted into bile following hepatic uptake by scavenger receptor class B type I (SR-BI). The present study aimed to determine the metabolic effects of an endothelial lipase (EL)-mediated stimulation of HDL cholesterol uptake on liver lipid metabolism and biliary cholesterol secretion in wild-type, SR-BI knockout, and SR-BI overexpressing mice. In each model, injection of an EL expressing adenovirus… CONTINUE READING

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