Hepatic Ito cells contain calcium channels: increases with transforming growth factor-beta 1.

@article{Oide1994HepaticIC,
  title={Hepatic Ito cells contain calcium channels: increases with transforming growth factor-beta 1.},
  author={H Oide and Ronald G. Thurman},
  journal={Hepatology},
  year={1994},
  volume={20 4 Pt 1},
  pages={1009-14}
}
Ito cells (fat-storing cells) have been implicated in mechanisms of liver fibrosis, and transforming growth factor-beta 1 is a key factor that stimulates collagen production by Ito cells. Moreover, Ito cells are reported to possess contractile proteins and to contract with ligands. We recently reported the presence of L-type voltage-operated Ca2+ channels in Kupffer cells. In this study, we examined whether Ito cells contain Ca2+ channels and also evaluated the effect of transforming growth… CONTINUE READING