Hepatic FGF21 mediates sex differences in high-fat high-fructose diet-induced fatty liver.

@article{Chukijrungroat2017HepaticFM,
  title={Hepatic FGF21 mediates sex differences in high-fat high-fructose diet-induced fatty liver.},
  author={Natsasi Chukijrungroat and Tanaporn Khamphaya and Jittima Weerachayaphorn and Thaweesak Songserm and Vitoon Saengsirisuwan},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2017},
  volume={313 2},
  pages={
          E203-E212
        }
}
The role of gender in the progression of fatty liver due to chronic high-fat high-fructose diet (HFFD) has not been studied. The present investigation assessed whether HFFD induced hepatic perturbations differently between the sexes and examined the potential mechanisms. Male, female, and ovariectomized (OVX) Sprague-Dawley rats were fed either a control diet or HFFD for 12 wk. Indexes of liver damage and hepatic steatosis were analyzed biochemically and histologically together with monitoring… CONTINUE READING
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