Hepatic Extraction of Hexarelin, a New Peptidic GH Secretagogue, in the Isolated Perfused Rat Liver


Purpose. To assess the hepatic extraction of hexarelin (HEX), a novel peptidyl GH secretagogue, in the isolated perfused rat model and document the in vitro binding of HEX to plasma proteins using plasma from rats, dogs, pigs, and humans. Methods. Rat liver was perfused in situ using a recirculating system. The recirculating perfusate consisted of a Krebs… (More)
DOI: 10.1023/A:1012193010009