Hepatic ERK activity plays a role in energy metabolism.

  title={Hepatic ERK activity plays a role in energy metabolism.},
  author={Ping Jiao and Bin Feng and Yujie Li and Qin He and Haiyan Xu},
  journal={Molecular and cellular endocrinology},
  volume={375 1-2},
Mitogen activated protein kinases (MAPKs), such as c-Jun N-terminal kinase (JNK) and P38, have been reported to play important roles in energy homeostasis. In this study, we show that the activity of extracellular signal-regulated kinase (ERK) is increased in the livers of diet induced and genetically obese mice. Activation of ERK in the livers of lean mice by over-expressing the constitutively active MAPK kinase 1 (MEK CA) results in decreased energy expenditure, lowered expression of genes… CONTINUE READING


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