Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice.

  title={Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice.},
  author={Pedro Elias Marques and Andr{\'e} Gustavo Fernandes Oliveira and Rafaela Vaz Sousa Pereira and Bruna Ara{\'u}jo David and Lindisley Ferreira Gomides and Adriana Machado Saraiva and Daniele Ara{\'u}jo Pires and J{\'u}lia Tosta Novaes and Daniel O. Patricio and Daniel Cisalpino and Z{\'e}lia Menezes-Garcia and W. Matthew Leevy and Sarah Ellen Chapman and Germ{\'a}nArturo Mahecha and Rafael Elias Marques and Rodrigo Guabiraba and Vicente de Paulo Martins and Danielle G Souza and Daniel Santos Mansur and Mauro M Teixeira and Maria de F{\'a}tima M. P. Leite and Gustavo Batista Menezes},
  volume={61 1},
UNLABELLED Drug-induced liver injury (DILI) is an important cause of acute liver failure, with limited therapeutic options. During DILI, oncotic necrosis with concomitant release and recognition of intracellular content amplifies liver inflammation and injury. Among these molecules, self-DNA has been widely shown to trigger inflammatory and autoimmune diseases; however, whether DNA released from damaged hepatocytes accumulates into necrotic liver and the impact of its recognition by the immune… CONTINUE READING
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