Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice.

Abstract

UNLABELLED Drug-induced liver injury (DILI) is an important cause of acute liver failure, with limited therapeutic options. During DILI, oncotic necrosis with concomitant release and recognition of intracellular content amplifies liver inflammation and injury. Among these molecules, self-DNA has been widely shown to trigger inflammatory and autoimmune… (More)
DOI: 10.1002/hep.27216

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