Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis


Liver plays a crucial role in controlling energy homeostasis in mammals, although the exact mechanism by which it influences other peripheral tissues has yet to be addressed. Here we show that Creb regulates transcriptional co-activator (Crtc) 2 is a major regulator of whole-body energy metabolism. Crtc2 liver-specific knockout lowers blood glucose levels… (More)
DOI: 10.1038/s41467-017-01878-6


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