Hepatic CYP3A Expression is Attenuated in Obese Mice Fed a High-Fat Diet

  title={Hepatic CYP3A Expression is Attenuated in Obese Mice Fed a High-Fat Diet},
  author={K. Yoshinari and Shunsuke Takagi and Teruyasu Yoshimasa and J. Sugatani and M. Miwa},
  journal={Pharmaceutical Research},
  • K. Yoshinari, Shunsuke Takagi, +2 authors M. Miwa
  • Published 2006
  • Chemistry, Medicine
  • Pharmaceutical Research
  • PurposeChanges in physiological, pathophysiological, and/or nutritional conditions often alter the expression of drug-metabolizing enzymes. In this study, we investigated obesity-induced changes in hepatic cytochrome P450 (P450) levels using nutritionally obese mice.MethodsTo induce obesity, mice were fed a high-fat diet or treated with gold thioglucose, which impairs ventromedial hypothalamus. Total RNAs and microsomal and nuclear proteins were prepared from the liver of these mice, and mRNA… CONTINUE READING
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