Hepatic CYP3A Expression is Attenuated in Obese Mice Fed a High-Fat Diet

@article{Yoshinari2006HepaticCE,
  title={Hepatic CYP3A Expression is Attenuated in Obese Mice Fed a High-Fat Diet},
  author={Kouichi Yoshinari and Shunsuke Takagi and Teruyasu Yoshimasa and Junko Sugatani and Masao Miwa},
  journal={Pharmaceutical Research},
  year={2006},
  volume={23},
  pages={1188-1200}
}
Changes in physiological, pathophysiological, and/or nutritional conditions often alter the expression of drug-metabolizing enzymes. In this study, we investigated obesity-induced changes in hepatic cytochrome P450 (P450) levels using nutritionally obese mice. To induce obesity, mice were fed a high-fat diet or treated with gold thioglucose, which impairs ventromedial hypothalamus. Total RNAs and microsomal and nuclear proteins were prepared from the liver of these mice, and mRNA and protein… CONTINUE READING
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