Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.

@article{OseiHyiaman2008HepaticCR,
  title={Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.},
  author={Douglas Osei-Hyiaman and Jie Liu and Liang Zhou and Grzegorz Godlewski and Judith Harvey-White and Won-il Jeong and S{\'a}ndor B{\'a}tkai and Giovanni Marsicano and Beat Lutz and Christoph Buettner and George Kunos},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 9},
  pages={3160-9}
}
Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and changes in plasma lipid profile. Endocannabinoids have been implicated in the development of these associated phenotypes, because mice deficient for the cannabinoid receptor CB1 (CB1-/-) do not display these changes in association with diet-induced obesity. The target tissues that mediate these effects, however, remain unknown. We therefore investigated the relative role of hepatic versus… CONTINUE READING