Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

@article{Bhatt2018HepaticAA,
  title={Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.},
  author={Deepak Kumar Bhatt and Abdul Basit and Haeyoung Zhang and Andrea Gaedigk and Seung-been Lee and Katrina G Claw and Aanchal Mehrotra and Amarjit Singh Chaudhry and Robin H. Pearce and Roger Gaedigk and Ulrich Broeckel and Timothy A. Thornton and Deborah A. Nickerson and Erin G. Schuetz and John K Amory and J Steven Leeder and Bhagwat Prasad},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2018},
  volume={46 6},
  pages={
          888-896
        }
}
The major objective of this study was to investigate the association of genetic and nongenetic factors with variability in protein abundance and in vitro activity of the androgen-metabolizing enzyme UGT2B17 in human liver microsomes (n = 455). UGT2B17 abundance was quantified by liquid chromatography-tandem mass spectrometry proteomics, and enzyme activity was determined by using testosterone and dihydrotestosterone as in vitro probe substrates. Genotyping or gene resequencing and mRNA… CONTINUE READING
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