Hepatic ACAT activity in African green monkeys is highly correlated to plasma LDL cholesteryl ester enrichment and coronary artery atherosclerosis.

@article{Carr1992HepaticAA,
  title={Hepatic ACAT activity in African green monkeys is highly correlated to plasma LDL cholesteryl ester enrichment and coronary artery atherosclerosis.},
  author={Timothy P. Carr and John S Parks and Lawrence Lee Rudel},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1992},
  volume={12 11},
  pages={1274-83}
}
Previous studies and this study of African green monkeys show a strong positive correlation between plasma low density lipoprotein (LDL) size and the extent of coronary artery atherosclerosis (CAA). Increased LDL size was principally due to the accumulation of cholesteryl oleate molecules within the particle core, suggesting that many of these cholesteryl esters were of tissue origin, i.e., from the acyl-coenzyme A:cholesterol acyltransferase (ACAT) reaction instead of the lecithin:cholesterol… CONTINUE READING
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Clair RW: Fish oil diet reduces binding of LDL and accumulation of cholesteryl ester in fibroblasts

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Fish oil diet reduces binding of LDL and accumulation of cholesteryl ester in fibroblasts

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Partial inhibition of ACAT decreases apoB secretion by the liver of African green monkeys, (abstract) Arteriosclerosis 1990;10:823a

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