Hepatic ABC transporters and triglyceride metabolism.

  title={Hepatic ABC transporters and triglyceride metabolism.},
  author={John S Parks and Soonkyu Chung and Gregory S. Shelness},
  journal={Current opinion in lipidology},
  volume={23 3},
PURPOSE OF REVIEW Elevated plasma triglyceride and reduced HDL concentrations are prominent features of metabolic syndrome and type 2 diabetes. Individuals with Tangier disease also have elevated plasma triglyceride concentrations and very low HDL, resulting from mutations in ATP-binding cassette transporter A1 (ABCA1), an integral membrane protein that facilitates nascent HDL particle assembly. Past studies attributed the inverse relationship between plasma HDL and triglyceride to… CONTINUE READING