Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis.

  title={Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis.},
  author={Sarah Konopelska and Tina Kienitz and Beverly Hughes and Matthias Pirlich and Juergen Bauditz and Herbert Lochs and Christian Joseph Strasburger and P. M. Stewart and Marcus Quinkler},
  journal={Clinical endocrinology},
  volume={70 4},
CONTEXT Nonalcoholic fatty liver disease represents the hepatic manifestation of the metabolic syndrome. Nonalcoholic steatohepatitis (NASH) is the progressive form of liver injury. The pathophysiology that leads to NASH is not well understood. OBJECTIVE We hypothesize that an altered cortisol metabolism in the liver may be a pathogenetic factor. DESIGN AND PATIENTS 75 patients (28 men, 47 women) underwent liver biopsy for elevation in liver enzymes. Histological diagnosis identified normal… CONTINUE READING
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