Heparitinase inhibition of mesoderm induction and gastrulation in Xenopus laevis embryos.

@article{Brickman1994HeparitinaseIO,
  title={Heparitinase inhibition of mesoderm induction and gastrulation in Xenopus laevis embryos.},
  author={Michael Brickman and John C. Gerhart},
  journal={Developmental biology},
  year={1994},
  volume={164 2},
  pages={484-501}
}
We have examined the involvement of proteoglycan molecules in the induction of mesodermal tissue in Xenopus laevis embryos. Blastocoelic injections of the enzyme heparitinase at early blastula stages lead to gastrulation defects and to failures in the development of anterior embryonic structures. The period of sensitivity of embryos to this treatment suggests a possible role for these molecules during mesoderm induction. We show that heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate… CONTINUE READING
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