Heparinization of a biomimetic bone matrix: integration of heparin during matrix synthesis versus adsorptive post surface modification.

@article{Knig2014HeparinizationOA,
  title={Heparinization of a biomimetic bone matrix: integration of heparin during matrix synthesis versus adsorptive post surface modification.},
  author={Ulla K{\"o}nig and Anja Lode and Petra Birgit Welzel and Yuichiro Ueda and Sven Knaack and Anja Henss and Anke Hauswald and Michael Gelinsky},
  journal={Journal of materials science. Materials in medicine},
  year={2014},
  volume={25 3},
  pages={607-21}
}
This study intended to evaluate a contemporary concept of scaffolding in bone tissue engineering in order to mimic functions of the extracellular matrix. The investigated approach considered the effect of the glycosaminoglycan heparin on structural and biological properties of a synthetic biomimetic bone graft material consisting of mineralized collagen. Two strategies for heparin functionalization were explored in order to receive a three-component bone substitute material. Heparin was either… CONTINUE READING