Heparin strongly enhances the formation of beta2-microglobulin amyloid fibrils in the presence of type I collagen.

@article{Relini2008HeparinSE,
  title={Heparin strongly enhances the formation of beta2-microglobulin amyloid fibrils in the presence of type I collagen.},
  author={Annalisa Relini and Silvia De Stefano and Silvia Torrassa and O Cavalleri and Ranieri Rolandi and Alessandra Gliozzi and Sofia Giorgetti and Sara Raimondi and Loredana Marchese and Laura Verga and Antonio Rossi and Monica Stoppini and Vittorio Bellotti},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 8},
  pages={4912-20}
}
The tissue specificity of fibrillar deposition in dialysis-related amyloidosis is most likely associated with the peculiar interaction of beta2-microglobulin (beta2-m) with collagen fibers. However, other co-factors such as glycosaminoglycans might facilitate amyloid formation. In this study we have investigated the role of heparin in the process of collagen-driven amyloidogenesis. In fact, heparin is a well known positive effector of fibrillogenesis, and the elucidation of its potential effect… CONTINUE READING

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beta(2)-microglobulin: from physiology to amyloidosis.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis • 2009
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Heparan Sulfate: Biosynthesis, Structure, and Function.

International review of cell and molecular biology • 2016
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