Heparin monitoring during cardiopulmonary bypass.

  title={Heparin monitoring during cardiopulmonary bypass.},
  author={Abdus Saleem and S S Shenaq and David H. Yawn and K Harshberger and Pierre A. Diemunsch and Pranshu Mohindra},
  journal={Annals of clinical and laboratory science},
  volume={14 6},
Three procedures have been compared for monitoring heparin in patients undergoing cardiopulmonary bypass: (1) activated clotting time (ACT) (2) protamine titration, and (3) fluorometric substrate assay. The ACT monitors the degree of anticoagulation. It is easy to perform and is relatively inexpensive, however, it does not correlate well with heparin levels and may not accurately predict the protamine dose for neutralization of heparin at the completion of bypass. A protamine titration assay or… CONTINUE READING