Heparin kinetics in venous thrombosis and pulmonary embolism.

@article{Hirsh1976HeparinKI,
  title={Heparin kinetics in venous thrombosis and pulmonary embolism.},
  author={Jesse Hirsh and W G van Aken and Alex S. Gallus and Colin T. Dollery and John F. Cade and W L Yung},
  journal={Circulation},
  year={1976},
  volume={53 4},
  pages={691-5}
}
The response to a standard dose of heparin was studied in 20 patients with venous thromboembolism. The heparin regimen consisted of intravenous injection of 70 units per kg, followed after 90 minutes by a maintenance dose of 400 units per kg per 24 hours given by continuous infusion. Plasma heparin activity and the activated partial thromboplastin time (APTT) were measured at intervals to determine clearance of the initial injection and the response to maintenance dose. Large inter-individual… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Heparinresistenz und Antithrombinmangel*

Medizinische Klinik • 2009
View 7 Excerpts
Highly Influenced

Hospital versus home treatment of deep vein thrombosis in a tertiary care hospital in Saudi Arabia: Are we ready?

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society • 2013
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 11 references

The kinetics of heparin.

Annals of the New York Academy of Sciences • 1971

A retrospective study of the pharmacokinetics of heparin

JW Estes
Clin Pharmacol Ther • 1969

Krugen-Thiemer E: A retrospective study of the pharmacokinetics of heparin

JW Estes, EW Pelikan
Clin Pharmacol Ther • 1969

The titration of heparin with protamine.

Scandinavian journal of clinical and laboratory investigation • 1954

Similar Papers

Loading similar papers…