Heparin is essential for a single keratinocyte growth factor molecule to bind and form a complex with two molecules of the extracellular domain of its receptor.

@article{Hsu1999HeparinIE,
  title={Heparin is essential for a single keratinocyte growth factor molecule to bind and form a complex with two molecules of the extracellular domain of its receptor.},
  author={Y. R. Hsu and Rebecca E. Nybo and Janis K Sullivan and V J Costigan and Chris Spahr and Cintyu Wong and Mark Jones and A G Pentzer and Jennifer Crouse and Robert E. Pacifici and Hsieng Sen Lu and Charles F. Morris and John S. Philo},
  journal={Biochemistry},
  year={1999},
  volume={38 8},
  pages={2523-34}
}
Keratinocyte growth factor (KGF or FGF-7) is a member of the heparin binding fibroblast growth factor (FGF) family and is a paracrine mediator of proliferation and differentiation of a wide variety of epithelial cells. To examine the stoichiometry of complexes formed between KGF and its receptor, we have utilized a soluble variant of the extracellular… CONTINUE READING