Heparin inhibits proliferation of myometrial and leiomyomal smooth muscle cells through the induction of alpha-smooth muscle actin, calponin h1 and p27.

@article{Horiuchi1999HeparinIP,
  title={Heparin inhibits proliferation of myometrial and leiomyomal smooth muscle cells through the induction of alpha-smooth muscle actin, calponin h1 and p27.},
  author={Akira Horiuchi and Toshio Nikaido and Z Ya-Li and Kiyoko Ito and Ayaka Orii and Shingo Fujii},
  journal={Molecular human reproduction},
  year={1999},
  volume={5 2},
  pages={139-45}
}
Mast cells are widely distributed in human tissues, including the human uterus. However, the function of mast cells in uterine smooth muscle has not been clearly established. Mast cells possess secretory granules containing such substances as heparin, serotonin, histamine and many cytokines. To help establish the role of mast cells in the human myometrium, the action of heparin was investigated using smooth muscle cells (SMC) from normal myometrium and from leiomyoma. The proliferation of… CONTINUE READING