Heparin-inhibitable lectin activity of the filamentous hemagglutinin adhesin of Bordetella pertussis.

@article{Menozzi1994HeparininhibitableLA,
  title={Heparin-inhibitable lectin activity of the filamentous hemagglutinin adhesin of Bordetella pertussis.},
  author={Franco Menozzi and Rebeka Mutombo and German F S{\'a}enz Renauld and C Gantiez and Julie H. Hannah and Elizabeth Leininger and Michael James William Brennan and Camille Locht},
  journal={Infection and immunity},
  year={1994},
  volume={62 3},
  pages={
          769-78
        }
}
Bordetella pertussis, the etiologic agent of whooping cough, produces an outer membrane-associated filamentous hemagglutinin (FHA) which is the major adhesin of this organism. FHA exhibits a lectin-like activity for heparin and dextran sulfate. By using in vitro adherence assays to cultured epithelial cells, the attachment of B. pertussis was reduced in the presence of sulfated polysaccharides such as heparin and dextran sulfate but not in the presence of dextran, indicating the crucial role of… CONTINUE READING

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