Heparin-induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests.

@article{Greinacher2010HeparininducedTT,
  title={Heparin-induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests.},
  author={Andreas Greinacher and Till Ittermann and Jessica Bagem{\"u}hl and Karina Althaus and Birgitt Fuerll and Sixten Selleng and Norbert Lubenow and Sebastian W Schellong and J I Sheppard and Theodore E Warkentin},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2010},
  volume={8 9},
  pages={2025-31}
}
BACKGROUND Laboratory confirmation of heparin-induced thrombocytopenia (HIT) is based on detection of heparin-dependent platelet-activating antibodies. Platelet factor 4 (PF4)/heparin enzyme-immunoassays (EIA) are a widely available surrogate for platelet-activating antibodies. OBJECTIVE Defining the optical density (OD) reactivity profiles of a PF4/heparin EIA in reference subject and patient populations and the correlation of the EIA results (expressed in OD units) with the prevalence of… CONTINUE READING

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Presence of antiheparin/platelet factor 4 immunoglobulin g is associated with poor prognosis in patients with suspected disseminated intravascular coagulation.

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