Heparin-induced thrombocytopenia: impact of bovine versus porcine heparin in HIT pathogenesis.

  • Sarfraz Ahmad
  • Published 2007 in
    Frontiers in bioscience : a journal and virtual…


Heparin-induced thrombocytopenia (HIT) is a complication of heparin therapy in cardiovascular/hematologic indications. Heparin is a mixture of sulfated mucopolysaccharide with heterogeneity and is capable of forming multiple complexes with platelet factor 4 (PF4), released from activated platelets. HPF4 antibodies may cause platelet/endothelial cell… (More)


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