Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain.

@article{Tan2008HeparininducedCA,
  title={Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain.},
  author={Kemin Tan and Mark A. Duquette and Jin-huan Liu and Kumaran Shanmugasundaram and Andrzej Joachimiak and John Thomas Gallagher and Alan C. Rigby and Jia-Huai Wang and Jack W Lawler},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 7},
  pages={3932-41}
}
Through its interactions with proteins and proteoglycans, thrombospondin-1 (TSP-1) functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular phenotype. We have previously determined the structure of the high affinity heparin-binding domain of TSP-1, designated TSPN-1, in association with the synthetic heparin, Arixtra. To establish that the binding of TSPN-1 to Arixtra is representative of the association with naturally occurring… CONTINUE READING

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