Heparin-immobilized biodegradable scaffolds for local and sustained release of angiogenic growth factor.

@article{Yoon2006HeparinimmobilizedBS,
  title={Heparin-immobilized biodegradable scaffolds for local and sustained release of angiogenic growth factor.},
  author={Jun Jin Yoon and Hyun Jung Chung and Hyuk Jin Lee and Tae Gwan Park},
  journal={Journal of biomedical materials research. Part A},
  year={2006},
  volume={79 4},
  pages={934-42}
}
Heparin-immobilized porous biodegradable scaffolds were fabricated to release basic fibroblast growth factor (bFGF) in a sustained manner. Heparin was covalently conjugated onto the surface of macroporous PLGA scaffolds fabricated by a gas-foaming/salt-leaching method. Sustained release of bFGF was successfully achieved for over 20 days due to high affinity of bFGF onto the immobilized heparin. It appears that bFGF release rate was regulated by the specific interaction between bFGF and heparin… CONTINUE READING