Heparin disaccharides inhibit tumor necrosis factor-alpha production by macrophages and arrest immune inflammation in rodents.

@article{Cahalon1997HeparinDI,
  title={Heparin disaccharides inhibit tumor necrosis factor-alpha production by macrophages and arrest immune inflammation in rodents.},
  author={Liora Cahalon and Ofer Lider and Heloisa H. R. Schor and Ann Avron and David Gilat and Rami Hershkoviz and Raanan Margalit and Amram Eshel and O Shoseyev and Irun R. Cohen},
  journal={International immunology},
  year={1997},
  volume={9 10},
  pages={
          1517-22
        }
}
Inflammation is the clinical expression of chemical mediators such as the pro-inflammatory cytokine tumor necrosis factor (TNF-)-alpha produced by macrophages and other cells activated in the immune response. Hence, agents that can inhibit TNF-alpha may be useful in treating arthritis and other diseases resulting from uncontrolled inflammation. We now report that the cleavage of heparin by the enzyme heparinase I generates sulfated disaccharide (DS) molecules that can inhibit the production of… CONTINUE READING

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