Heparin-disaccharide affects T cells: inhibition of NF-kappaB activation, cell migration, and modulation of intracellular signaling.

@article{Hecht2004HeparindisaccharideAT,
  title={Heparin-disaccharide affects T cells: inhibition of NF-kappaB activation, cell migration, and modulation of intracellular signaling.},
  author={Iris Hecht and Rami Hershkoviz and Shoham Shivtiel and Tzvi Lapidot and Irun R. Cohen and Ofer Lider and Liora Cahalon},
  journal={Journal of leukocyte biology},
  year={2004},
  volume={75 6},
  pages={
          1139-46
        }
}
We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-1beta] secretion by T cells, macrophages, or intestinal epithelial cells. Here, we investigated the effects of a trisulfated heparin DS (3S-DS) on two aspects of T cell function: secretion of proinflammatory cytokines and migration to an… CONTINUE READING

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