Heparin-derived supersulfated disaccharide inhibits allergic airway responses in sheep.


The tetrasaccharide sequence of heparin oligosaccharides is the minimum chain length possessing anti-allergic activity, as the disaccharide fraction is inactive. Since sulfation pattern can modify the biological actions of heparin, we hypothesized that "supersulfation" of the inactive heparin disaccharide could confer anti-allergic activity to this molecule… (More)
DOI: 10.1016/j.pupt.2013.12.001


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