Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer.

@article{Casu2010HeparinderivedHS,
  title={Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer.},
  author={Benito Casu and Annamaria Naggi and Giangiacomo Torri},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2010},
  volume={29 6},
  pages={442-52}
}
The heparan sulfate (HS) chains of heparan sulfate proteoglycans (HSPG) are "ubiquitous" components of the cell surface and the extracellular matrix (EC) and play important roles in the physiopathology of developmental and homeostatic processes. Most biological properties of HS are mediated by interactions with "heparin-binding proteins" and can be modulated by exogenous heparin species (unmodified heparin, low molecular weight heparins, shorter heparin oligosaccharides and various non… CONTINUE READING
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