Heparin decreases the blood clearance of interferon-gamma and increases its activity by limiting the processing of its carboxyl-terminal sequence.

@article{LortatJacob1996HeparinDT,
  title={Heparin decreases the blood clearance of interferon-gamma and increases its activity by limiting the processing of its carboxyl-terminal sequence.},
  author={Hugues Lortat-Jacob and Franziska Baltzer and Jean - Alexis Grimaud},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 27},
  pages={16139-43}
}
Interferon-gamma (IFN-gamma) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain. In vivo, IFN-gamma is eliminated from the bloodstream with a half-life (t1/2) of 1.1 min, due to binding to heparan sulfate. Unbound IFN-gamma is cleaved rapidly at the carboxyl-terminal side, a process that removes at least 18 amino acids and inactivates the cytokine. When bound to heparin, the plasma clearance of IFN-gamma is decreased greatly (t1/2 = 99 min… CONTINUE READING