Heparin cofactor II-proteinase reaction products exhibit neutrophil chemoattractant activity.

  title={Heparin cofactor II-proteinase reaction products exhibit neutrophil chemoattractant activity.},
  author={Marion Hoffman and Carlos W. Pratt and Ronald Lane Brown and Frank C. Church},
  volume={73 6},
The physiologic function of the plasma glycoprotein heparin cofactor II (HCII) is not well understood. An in vivo role for thrombin (IIa) inhibition by HCII in the presence of certain glycosaminoglycans (dermatan sulfate and heparin) can be proposed. Many proteins, such as complement components, can be proteolyzed to generate secondary bioactive molecules. HCII is a substrate for the human neutrophil (PMN) proteinases cathepsin G (CG) and elastase (LE). We found that degradation of HCII by CG… CONTINUE READING


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