Heparin coating durability on artificial heart valves studied by XPS and antithrombin binding capacity.

@article{Kristensen2006HeparinCD,
  title={Heparin coating durability on artificial heart valves studied by XPS and antithrombin binding capacity.},
  author={Emma M E Kristensen and Rolf Larsson and Javier Bl{\'a}zquez S{\'a}nchez and H{\aa}kan Rensmo and Ulrik Gelius and Hans Siegbahn},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2006},
  volume={49 1},
  pages={1-7}
}
The durability and functionality of a heparin coating on artificial heart valve leaflets were evaluated with X-ray photoelectron spectroscopy (XPS) and by the coatings' capacity to bind antithrombin. Current methods for accelerated life-time testing are based on exposing leaflets to water solutions. In this paper a method is explored, in which heart valve leaflets were exposed to a continuous high shear rate (4 L/min) of human citrated plasma. It was found that the heparin coating was stable… CONTINUE READING

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