Heparin-coated polyacrylonitrile membrane versus regional citrate anticoagulation: a prospective randomized study of 2 anticoagulation strategies in patients at risk of bleeding.

@article{Evenepoel2007HeparincoatedPM,
  title={Heparin-coated polyacrylonitrile membrane versus regional citrate anticoagulation: a prospective randomized study of 2 anticoagulation strategies in patients at risk of bleeding.},
  author={P. Evenepoel and Tom Dejagere and Peter Verhamme and Kathleen J Claes and Dirk Kuypers and Bert Bammens and Yves F Ch Vanrenterghem},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2007},
  volume={49 5},
  pages={
          642-9
        }
}
BACKGROUND Hemodialysis requires anticoagulation to prevent clotting of the extracorporeal circuit. Systemic anticoagulation with heparin is contraindicated in patients at high risk of bleeding. In these patients, regional citrate anticoagulation (RCA), with either calcium-free (RCA-Ca0) or calcium-containing dialysate (RCA-Ca3.0), and heparin-coated membranes (1.3 m(2); AN69ST; Nephral 300ST, Gambro-Hospal, Meyzieu, France) may represent valid alternatives. METHODS To compare the efficacy… CONTINUE READING

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