Heparin bonding of bypass circuits reduces cytokine release during cardiopulmonary bypass.

@article{Steinberg1995HeparinBO,
  title={Heparin bonding of bypass circuits reduces cytokine release during cardiopulmonary bypass.},
  author={Bryan M Steinberg and Eugene A Grossi and Daniel S. Schwartz and David E McLoughlin and M{\'o}nica Aguinaga and Costas S Bizekis and Jeffrey Greenwald and Ana Flisser and Frank C. Spencer and Aubrey C. Galloway},
  journal={The Annals of thoracic surgery},
  year={1995},
  volume={60 3},
  pages={525-9}
}
BACKGROUND Heparin bonding of the cardiopulmonary bypass (CPB) pump circuit decreases complement activation and fibrinolysis. It is not known whether inflammatory cytokines produced during CPB can also be modulated by the more biocompatible heparin-coated circuit. METHODS This initial study evaluated the impact of heparin-bonded CPB circuits on production of the cytokines interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-a), IL-6, and IL-8 in adults undergoing complex cardiac operations… CONTINUE READING

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