Heparin binds to Leishmania donovani promastigotes and inhibits protein phosphorylation.

@article{Mukhopadhyay1989HeparinBT,
  title={Heparin binds to Leishmania donovani promastigotes and inhibits protein phosphorylation.},
  author={Nupur Mukhopadhyay and Kuntala Shome and Asish Kumar Saha and J. Hassell and Robert Hayes Glew},
  journal={The Biochemical journal},
  year={1989},
  volume={264 2},
  pages={
          517-25
        }
}
We show that promastigotes of Leishmania donovani, the causative agent of visceral leishmaniasis (kala-azar), possess heparin receptors on their surface. From a linear Scatchard plot of the binding data obtained using [3H]heparin and viable promastigotes, one derives a binding constant of 4.7 x 10(-7) M and an estimate of 860,000 receptors per parasite. The [3H]heparin bound to parasites could not be displaced by hyaluronic acid or by three other glycosaminoglycans (dermatan sulphate… CONTINUE READING
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