Heparin binding to resting and activated platelets.

  title={Heparin binding to resting and activated platelets.},
  author={M K Horne and Eddie S. Chao},
  volume={74 1},
Heparin inhibits platelet function and can cause thrombocytopenia. In an effort to understand these phenomena, we have measured the binding of (3H)-heparin to resting and stimulated platelets. In platelet-rich plasma, a single class of saturable heparin binding sites was observed (apparent dissociation constant [kd] approximately 0.55 microgram/mL, R approximately 0.059 microgram/10(9) cells). In gel-filtered platelets, a similar class of sites was present but with a greater binding capacity… CONTINUE READING