Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

@article{Kan1989HeparinbindingGF,
  title={Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.},
  author={Mikio Kan and Jung San Huang and Per E. M{\aa}nsson and Hidetaro Yasumitsu and Boyd Carr and Wallace L. Mckeehan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 19},
  pages={7432-6}
}
Heparin-binding growth factor type 1 (HBGF-1; sometimes termed acidic fibroblast growth factor) is potentially an important factor in liver regeneration. HBGF-1 alone (half-maximal effect at 60 pM) stimulated hepatocyte DNA synthesis and bound to a high-affinity receptor (Kd = 62 pM; 5000 per cell). Epidermal growth factor (EGF) neutralized or masked the mitogenic effect of HBGF-1 concurrent with appearance of low-affinity HBGF-1 binding sites. HBGF-1 reduced the inhibitory effect of… CONTINUE READING

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