Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling.

@article{Zhang2008HeparinbindingEG,
  title={Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling.},
  author={Hua Zhang and Susan Wohler Sunnarborg and Kirk K. McNaughton and Terrance G Johns and David S. C. Lee and James E. Faber},
  journal={Circulation research},
  year={2008},
  volume={102 10},
  pages={
          1275-85
        }
}
Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is activated by reduced endothelial shear stress and stimulates smooth muscle cell proliferation in vitro. Moreover, HB-EGF is augmented at sites of intimal hyperplasia and atherosclerosis, conditions favored by low/disturbed shear stress. We thus tested whether HB-EGF contributes to low flow-induced negative hypertrophic remodeling (FINR) of a mouse carotid artery. Blood flow was surgically decreased in the left and… CONTINUE READING
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