Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function.

@article{Adam2002HeparinbindingEG,
  title={Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function.},
  author={Rosalyn M Adam and Jayoung Kim and Jianqing Lin and Anna Orsola and Liyan Zhuang and Dana C Rice and Michael R. Freeman},
  journal={Endocrinology},
  year={2002},
  volume={143 12},
  pages={4599-608}
}
Peptide growth factors have been implicated in progression of prostate cancer (PCa) to the androgen-independent state; however, much of the evidence linking diffusible mitogens and survival factors to this process remains circumstantial. Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a prostate stroma-derived factor, promotes survival, proliferation, and neuroendocrine differentiation of androgen-dependent LNCaP PCa cells in vitro. To test whether sustained exposure to HB… CONTINUE READING

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Fibroblast growth factor 2: its structure and property, paracrine function, tumor angiogenesis, and prostate-related mitogenic and oncogenic functions

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