Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst

@article{Chobotova2002HeparinbindingEG,
  title={Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst},
  author={Katya Chobotova and Isabella Spyropoulou and Janet Carver and Sanjiv Manek and John K. Heath and William J. Gullick and David H Barlow and Ian I L Sargent and Helen J. Mardon},
  journal={Mechanisms of Development},
  year={2002},
  volume={119},
  pages={137-144}
}
The mechanisms that mediate implantation of the human embryo remain poorly understood and represent a fundamental problem in reproductive biology. Candidate molecules that mediate and facilitate implantation have been identified in animal studies, and include heparin binding epidermal growth factor. Here we demonstrate a potential function for the transmembrane form of heparin-binding epidermal growth factor in mediating blastocyst attachment to the endometrium, in two different novel in vitro… CONTINUE READING