Heparin-binding domains in vascular biology.

  title={Heparin-binding domains in vascular biology.},
  author={Eva Ma Mart{\'i}nez Mu{\~n}oz and Robert J. Linhardt},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={24 9},
Heparin is a major anticoagulant with activity mediated primarily through its interaction with antithrombin (AT). Heparan sulfate (HS), structurally related to heparin, binds a wide range of proteins of different functionality, taking part in various physiological and pathological processes. The heparin-AT complex, the most well understood facet of anticoagulation, serves as a prototypical example of the important role of heparin/HS in vascular biology. Extensive studies have identified common… CONTINUE READING
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