Heparin binding domain in vitronectin is required for oligomerization and thus enhances integrin mediated cell adhesion and spreading.

@article{Chillakuri2010HeparinBD,
  title={Heparin binding domain in vitronectin is required for oligomerization and thus enhances integrin mediated cell adhesion and spreading.},
  author={Chandramouli R. Chillakuri and C{\'e}line Jones and Helen J. Mardon},
  journal={FEBS letters},
  year={2010},
  volume={584 15},
  pages={3287-91}
}
Vitronectin is a multi-functional protein found predominantly as a monomer in blood and as an oligomer in the extracellular matrix. We have dissected the minimal regions of vitronectin protein needed for effective integrin dependent cell adhesion and spreading. A fragment of vitronectin containing the RGD integrin binding site showed similar binding affinity as that of full vitronectin protein to purified integrin alphavbeta3 but had diminished cell adhesion and spreading function in vivo. We… CONTINUE READING

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