Heparin-binding domain, type 1 and type 2 repeats of thrombospondin mediate its interaction with human breast cancer cells.

@article{Incardona1996HeparinbindingDT,
  title={Heparin-binding domain, type 1 and type 2 repeats of thrombospondin mediate its interaction with human breast cancer cells.},
  author={Francesca Incardona and Jack W Lawler and Daniel H. Cataldo and Amos Panet and Yves J. Legrand and Jean Michel Foidart and Chantal Legrand},
  journal={Journal of cellular biochemistry},
  year={1996},
  volume={62 4},
  pages={431-42}
}
Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains of thrombospondin that mediate its binding to specific receptors on the human breast adenocarcinoma cell line, MDA-MB-231. Two recombinant fragments from the amino-terminus (TSPN18 and TSPN28), and the fusion proteins of the type 1 and type 2 repeats of human thrombospondin, inhibited binding of… CONTINUE READING