Heparin-binding EGF-like growth factor.

  title={Heparin-binding EGF-like growth factor.},
  author={Gerhard Raab and Michael Klagsbrun},
  journal={Biochimica et biophysica acta},
  volume={1333 3},
HB-EGF is a heparin-binding member of the EGF family that was initially identified in the conditioned medium of human macrophages. Soluble mature HB-EGF is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells but not endothelial cells. HB-EGF activates two EGF receptor subtypes, HER1 and HER4 and binds to cell surface HSPG. The transmembrane form of HB-EGF is a juxtacrine growth and adhesion… CONTINUE READING
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