Heparin-binding EGF-like growth factor decreases apoptosis in intestinal epithelial cells in vitro.

@article{Michalsky2001HeparinbindingEG,
  title={Heparin-binding EGF-like growth factor decreases apoptosis in intestinal epithelial cells in vitro.},
  author={Marc P. Michalsky and Annette Kuhn and Veela Mehta and Gail E. Besner},
  journal={Journal of pediatric surgery},
  year={2001},
  volume={36 8},
  pages={1130-5}
}
BACKGROUND/PURPOSE The production of heparin-binding EGF-like growth factor (HB-EGF) is upregulated during organ injury and has a cytoprotective effect during hypoxic stress in intestinal epithelial cells in vitro and intestinal ischemia-reperfusion injuries in vivo. The purpose of this study was to determine if HB-EGF-related cytoprotection is manifested through alterations in apoptosis. METHODS Human intestinal epithelial cell monolayers (DLD-1 and Caco-2) were stimulated with interleukin… CONTINUE READING