Heparin-binding EGF-like growth factor decreases neutrophil-endothelial cell interactions.

@article{Rocourt2007HeparinbindingEG,
  title={Heparin-binding EGF-like growth factor decreases neutrophil-endothelial cell interactions.},
  author={Dorothy V. Rocourt and Veela B. Mehta and Dan Wu and Gail E. Besner},
  journal={The Journal of surgical research},
  year={2007},
  volume={141 2},
  pages={
          262-6
        }
}
BACKGROUND Hyperadhesiveness of neutrophils (PMN) to vascular endothelial cells (EC) followed by neutrophil transendothelial migration play important roles in the initiation of ischemia/reperfusion (I/R)-mediated injury. We investigated whether the ability of heparin-binding EGF-like growth factor (HB-EGF) to decrease intestinal injury after intestinal I/R is mediated, in part, by its ability to affect PMN-EC interactions and EC junctional integrity. MATERIALS AND METHODS Human umbilical vein… CONTINUE READING
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