Heparin-binding EGF-like factor augments esophageal epithelial cell proliferation, migration and inhibits TRAIL-mediated apoptosis via EGFR/MAPK signaling.

@article{Rahman2010HeparinbindingEF,
  title={Heparin-binding EGF-like factor augments esophageal epithelial cell proliferation, migration and inhibits TRAIL-mediated apoptosis via EGFR/MAPK signaling.},
  author={Farzana Binte Rahman and Shunji Ishihara and M D Monowar Aziz and Yoshiyuki Mishima and Naoki Oshima and Yong-yu Li and Alvaro Adolfo Sanchez-Siles and Aya Otani and Akihiko Oka and Ryusaku Kusunoki and Yasumasa Tada and Ichiro Moriyama and Norihisa Ishimura and Takafumi Yuki and Hideaki Kazumori and Yuji Amano and Shuichi Sato and Mesban Uddin Ansary and Yoshikazu Kinoshita},
  journal={Scandinavian journal of gastroenterology},
  year={2010},
  volume={45 11},
  pages={1350-9}
}
OBJECTIVE Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been shown to stimulate the growth and migration of human keratinocytes in an autocrine or paracrine manner. Bearing in mind the preceding narratives, present study was designed to explore the role of HB-EGF on esophageal epithelial cell growth, migration and anti-apoptosis. MATERIAL AND METHODS HET-1A and TTn cells were treated with recombinant HB-EGF, and cell proliferation and migration were assessed by MTT… CONTINUE READING

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