Heparin attenuates cytotoxic and inflammatory activity of Alzheimer amyloid-beta in vitro.

@article{Bergamaschini2002HeparinAC,
  title={Heparin attenuates cytotoxic and inflammatory activity of Alzheimer amyloid-beta in vitro.},
  author={Luigi Bergamaschini and Cesare Donarini and Emanuela Rossi and Ada De Luigi and Carlo Vergani and Maria-Grazia De Simoni},
  journal={Neurobiology of aging},
  year={2002},
  volume={23 4},
  pages={531-6}
}
Amyloid-beta protein (Abeta) is implicated in the pathogenesis of Alzheimer's disease because of its neurotoxicity and the ability to trigger local inflammation. Compounds that interact with the amino acids of the N-terminal region or interfere with aggregation can reduce the Abeta biologic activity. We evaluated the effect of heparin on Abeta (1-42) neurotoxicity and on its ability to activate complement and contact system. On differentiated PC12 cells, a reliable model of neuronal cells… CONTINUE READING

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