Heparin and the phenotype of adult human vascular smooth muscle cells

@article{Sorger2007HeparinAT,
  title={Heparin and the phenotype of adult human vascular smooth muscle cells},
  author={Thomas Sorger and Nancy A. Friday and Lingchao Yang and Elliot M. Levine},
  journal={In Vitro Cellular \& Developmental Biology - Animal},
  year={2007},
  volume={31},
  pages={671-683}
}
SummaryTo study mechanisms controlling growth and phenotype in human vascular smooth muscle cells, we established culture conditions under which these cells proliferate rapidly and achieve life-spans of 50–60 population doublings. In medium containing heparin and heparin-binding growth factors, growth rate and life-span of human vascular smooth muscle cells increased more than 50% relative to cultures with neither supplement, and more than 20% compared to cultures supplemented only with heparin… 
2 Citations
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LPP appears to be a myocardin-, RhoA/ROK-dependent SMC differentiation marker that plays a role in regulating SMC migration.
LPP Expression During In Vitro Smooth Muscle Differentiation and Stent-Induced Vascular Injury
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LPP appears to be a myocardin-, RhoA/ROK-dependent SMC differentiation marker that plays a role in regulating SMC migration.

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