Heparin and protamine titration do not improve haemostasis in cardiac surgical patients.

Abstract

PURPOSE Weight-based heparin and protamine dosing strategies for cardiopulmonary bypass (CPB) do not take into account interpatient variability in drug sensitivity and may result in bleeding complications. We compared the Hemochron RxDx heparin and protamine titration system with standard weight based management with regard to heparin dose, protamine dose… (More)

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@article{ShoreLesserson1998HeparinAP, title={Heparin and protamine titration do not improve haemostasis in cardiac surgical patients.}, author={Linda J. Shore-Lesserson and Dan Reich and M DePerio}, journal={Canadian journal of anaesthesia = Journal canadien d'anesthesie}, year={1998}, volume={45 1}, pages={10-8} }